Development and incorporation of nanoemulsions in food

Antonio de J. Cenobio-Galindo ,
Antonio de J. Cenobio-Galindo

Instituto de Ciencias Agropecuarias, Universidad Aut´onoma del Estado de Hidalgo. Av. Rancho Universitario Mexico

Rafael G. Campos-Montiel ,
Rafael G. Campos-Montiel

Instituto de Ciencias Agropecuarias, Universidad Aut´onoma del Estado de Hidalgo. Av. Rancho Universitario Mexico

Ruben´ Jimenez-Alvarado ,
Ruben´ Jimenez-Alvarado
Contact Ruben´ Jimenez-Alvarado

Instituto de Ciencias Agropecuarias, Universidad Aut´onoma del Estado de Hidalgo. Av. Rancho Universitario Mexico

Isaac Almaraz-Buend´ıa ,
Isaac Almaraz-Buend´ıa

Instituto de Ciencias Agropecuarias, Universidad Aut´onoma del Estado de Hidalgo. Av. Rancho Universitario Mexico

Gabriela Medina-Perez ,
Gabriela Medina-Perez

DCTS, Cinvestav-Zacatengo, Ciudad de M´exico Mexico

Fabian Fern ´ andez-Luque ´ no
Fabian Fern ´ andez-Luque ´ no

Sustainability of Natural Resources and Energy Program, Cinvestav-Saltillo , Coahuila , Mexico

Published: 18.10.2019.

Volume 8, Issue 2 (2019)

pp. 105-124;

https://doi.org/10.7455/ijfs/8.2.2019.a10

Abstract

Currently, nanoencapsulation of bioactive compounds is promising, and is one of the methods that has been proven very effective. The development of food-grade nanoemulsions is in a state of constant innovation due to the interesting features that this method of encapsulation has, such as small droplet size, kinetic stability and appearance. With this technology, it is possible to control some food properties, such as texture, taste and stability. In this article, we present a review of the most commonly used methods in the creation of nanoemulsions, the recent developments of these dispersions, the relevant applications of nanoemulsions in food matrices, the most commonly used food-grade materials and the functionality of nanoemulsions, which are designed primarily to encapsulate compounds with biological activity. Nanoemulsions have been shown to be effective in preventing degradation and improving the bioavailability of bioactive compounds, such as oil-soluble vitamins, antimicrobials, flavours and antioxidants. At the end of this article, facts of interest about acceptance issues and nanotechnology regulatory policies in the food industry are presented.

Keywords

References

1.
Abdou E, Galhoum G, Mohamed E. Curcumin loaded nanoemulsions/pectin coatings for refrigerated chicken fillets. Food Hydrocolloids. 2018;445–53.
2.
Acosta E. Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Current Opinion in Colloid & Interface Science. 2009;(1):3–15.
3.
IJFS October. 2019;105–24.
4.
Ahmed K, Li Y, Mcclements D, Xiao H. Nanoemulsion-and emulsionbased delivery systems for curcumin: Encapsulation and release properties. Food Chemistry. 2012;(2):799–807.
5.
Amenta V, Aschberger K, Arena M, Bouwmeester H, Moniz F, Brandhoff P, et al. Regulatory aspects of nanotechnology in the agri/feed/food sector in eu and non-eu countries. Regulatory Toxicology and Pharmacology. 2015;(1):463–76.
6.
Robles-Garcia A, Rodriguez-Felix M, Marquez-Rios F, Antonio Aguilar E, Barrera-Rodriguez J, Aguilar A, et al. Applications of nanotechnology in the agriculture, food, and pharmaceuticals. Journal of Nanoscience and Nanotechnology. 2016;(8):8188–207.
7.
Anton N, Gayet P, Benoit JP, Saulnier P. Conference on New Trends in Drug Delivery Systems. International Journal of Pharmaceutics. 2007;(1–2):44–52.
8.
Anton N, Vandamme T. The universality of low-energy nano-emulsification. International Journal of Pharmaceutics. 2009;(1–2):142–7.
9.
Aquanova. Crystal clear solutions. Overview. 2016;
10.
Artiga M, Fani A, Martin-Belloso O. Improving the shelf life of low-fat cut cheese using nanoemulsion-based edible coatings containing oregano essential oil and mandarin fiber. Food Control. 2017;1–12.
11.
Bhargava K, Conti D, Da Rocha S, Zhang Y. Application of an oregano oil nanoemulsion to the control of foodborne bacteria on fresh lettuce. Food Microbiology. 2015;69–73.
12.
Bouwmeester H, Dekkers S, Noordam M, Hagens W, Bulder A, De Heer C, et al. Review of health safety aspects of nanotechnologies in food production. Regulatory toxicology and pharmacology. 2009;(1):52–62.
13.
Buranasuksombat U, Kwon Y, Turner M, Bhandari B. Influence of emulsion droplet size on antimicrobial properties. Food Science and Biotechnology. 2011;(3):793–800.
14.
Capek I. Degradation of kineticallystable o/w emulsions. Advances in Colloid and Interface Science. 2004;(2–3):125–55.
15.
Chang Y, Mclandsborough L, Mcclements D. Physical properties and antimicrobial efficacy of thyme oil nanoemulsions: Influence of ripening inhibitors. Journal of Agricultural and Food Chemistry. 2012;(48):12056–63.
16.
Chau CF, Wu SH, Yen GC. The development of regulations for food nanotechnology. Trends in Food Science & Technology. 2007;(5):269–80.
17.
Choi AJ, Kim CJ, Cho YJ, Hwang JK, Kim CT. Characterization of capsaicin-loaded nanoemulsions stabilized with alginate and chitosan by selfassembly. Food and Bioprocess Technology. 2011;(6):1119–26.
18.
Chuesiang P, Siripatrawan U, Sanguandeekul R, Mclandsborough L, Mcclements D. Optimization of cinnamon oil nanoemulsions using phase inversion temperature method: Impact of oil phase composition and surfactant concentration. Journal of Colloid and Interface Science. 2018;208–16.
19.
De Carli C, Moraes-Lovison M, Pinho S. Production, physicochemical stability of quercetin-loaded nanoemulsions and evaluation of antioxidant activity in spreadable chicken pâtés. LWT-Food Science and Technology. 2018;98.
20.
Dickinson E. th International Hydrocolloids Conference, Singapore. 2009;(6).
21.
Donsi F, Cuomo A, Marchese E, Ferrari G. Infusion of essential oils for food stabilization: Unraveling the role of nanoemulsion-based delivery systems on mass transfer and antimicrobial activity. Innovative Food Science & Emerging Technologies. 2014;212–20.
22.
Donsi F, Ferrari G. Essential oil nanoemulsions as antimicrobial agents. Journal of Biotechnology. 2016;106–20.
23.
Dreher K. Health and environmental impact of nanotechnology: Toxicological assessment of manufactured nanoparticles. Toxicological Sciences. 2004;(1):3–5.
24.
Duncan T. Applications of nanotechnology in food packaging and food safety: Barrier materials, antimicrobials and sensors. Journal of Colloid and Interface Science. 2011;(1):1–24.
25.
Galvão K, Vicente A, Sobral P. Development, characterization, and stability of o/w pepper nanoemulsions produced by high-pressure homogenization. Food and bioprocess technology. 2018;(2):355–67.
26.
Gharibzahedi S, Mousavi S, Hamedi M, Ghasemlou M. Response surface modeling for optimization of formulation variables and physical stability assessment of walnut oil-in-water beverage emulsions. Food Hydrocolloids. 2012;(1):293–301.
27.
Ghosh V, Mukherjee A, Chandrasekaran N. Ultrasonic emulsification of foodgrade nanoemulsion formulation and evaluation of its bactericidal activity. 2013;(1):338–44.
28.
Ghosh V, Mukherjee A, Chandrasekaran N. Eugenol-loaded antimicrobial nanoemulsion preserves fruit juice against, microbial spoilage. Colloids and Surfaces B-biointerfaces. 2014;392–7.
29.
Golfomitsou I, Mitsou E, Xenakis A, Papadimitriou V. Development of food grade o/w nanoemulsions as carriers of vitamin d for the fortification of emulsion based food matrices: A structural and activity study. Journal of Molecular Liquids. 2018;734–42.
30.
Gothsch T, Finke J, Beinert S, Lesche C, Schur J, Buettgenbach S, et al. Effect of microchannel geometry on high-pressure dispersion and emulsification. Chemical Engineering & Technology. 2011;(3):335–43.
31.
Graves S, Meleson K, Wilking J, Lin M, Mason T. Structure of concentrated nanoemulsions. Journal of Chemical Physics. 2005;(13):122.
32.
Guler E, Barlas F, Yavuz M, Demir B, Gumus Z, Baspinar Y, et al. Bio-active nanoemulsions enriched with gold nanoparticle, marigold extracts and lipoic acid: In vitro investigations. Colloids and Surfaces B-biointerfaces. 2014;299–306.
33.
Gumus Z, Guler E, Demir B, Barlas F, Yavuz M, Colpankan D, et al. Herbal infusions of black seed and wheat germ oil: Their chemical profiles, in vitro bio-investigations and effective formulations as phyto-nanoemulsions. Colloids and Surfaces B-biointerfaces. 2015;73–80.
34.
Gupta A, Eral H, Hatton T, Doyle P. Nanoemulsions: Formation, properties and applications. Soft Matter. 2016;(11):2826–41.
35.
Ijfs October. 2019;119.
36.
Gutierrez J, Gonzalez C, Maestro A, Sole I, Pey C, Nolla J. Nanoemulsions: New applications and optimization of their preparation. Current Opinion in Colloid & Interface Science. 2008;(4):245–51.
37.
Hernandez-Fuentes A, Trapala-Islas A, Gallegos-Vasquez C, Campos-Montiel R, Pinedo-Espinoza J, Guzman-Maldonado S. Physicochemical variability and nutritional and functional characteristics of xoconostles (opuntia spp.) accessions from mexico. Fruits. 2015;(2):109–16.
38.
Guerra-Rosas I, Morales-Castro M, J, Ochoa-Martinez A, Salvia-Trujillo L, Martin-Belloso L, et al. Long-term stability of food-grade nanoemulsions from high methoxyl pectin containing essential oils. Food Hydrocolloids. 2016;438–46.
39.
Jafari S, Assadpoor E, He Y, Bhandari B. Re-coalescence of emulsion droplets during high-energy emulsification. Food Hydrocolloids. 2008;(7):1191–202.
40.
Jin W, Xu W, Liang H, Li Y, Liu S, Li B. Emulsions. Nanotechnology in the Agri-Food Industry. 2016;1–36.
41.
Jo WS, Song HY, Song NB, Lee JH, Min S, Song K. Quality and microbial safety of “fuji” apples coated with carnauba-shellac wax containing lemongrass oil. 2014;(2):490–7.
42.
Jo YJ, Chun JY, Kwon YJ, Min SG, Hong GP, Choi MJ. Physical and antimicrobial properties of transcinnamaldehyde nanoemulsions in water melon juice. LWT-Food Science and Technology. 2015;(1):444–51.
43.
Joung H, Choi MJ, Kim J, Park S, Park J, Hwa Shin H, et al. Development of food-grade curcumin nanoemulsion and its potential application to food beverage system: Antioxidant property and in vitro digestion. Journal of food science. 2016;81.
44.
Jovanovic B. Critical review of public health regulations of titanium dioxide, a human food additive. Integrated Environmental Assessment and Management. 2015;(1):10–20.
45.
Kabalnov A, Shchukin E. Ostwald ripening theory-applications to fluorocarbon emulsion stability. Advances in Colloid and Interface Science. 1992;69–97.
46.
Khaled F, Ramadan A, Ashoush I. Nanoencapsulation and nanoemulsion of bioactive compounds to enhance their antioxidant activity in food. International Journal of Food Science and Technology. 2014;(3):1–22.
47.
Kim IH, Oh Y, Lee H, Bin, Song K, Min S. Grape berry coatings of lemongrass oil-incorporating nanoemulsion. LWT-Food Science and Technology. 2014;(1):1–10.
48.
Landsiedel R, Fabian E, Ma-Hock L, Wohlleben W, Wiench K, Oesch F, et al. Toxico-/biokinetics of nanomaterials. Archives of Toxicology. 2012;(7):1021–60.
49.
Lee L, Norton I. Comparing droplet breakup for a high-pressure valve homogeniser and a microfluidizer for the potential production of food-grade nanoemulsions. Journal of Food Engineering. 2013;(2):158–63.
50.
Liu F, Avena-Bustillos R, Chiou BS, Li Y, Ma Y, Williams T, et al. Controlled-release of tea polyphenol from gelatin films incorporated with different ratios of free/nanoencapsulated tea polyphenols into fatty food simulants. Food Hydrocolloids. 2017;212–21.
51.
Lu W, Kelly A, Miao S. Trends in Food Science & Technology. 2016;1–9.
52.
Lu WC, Huang DW, Wang CC, Yeh CH, Tsai JC, Huang YT, et al. Preparation, characterization, and antimicrobial activity of nanoemulsions incorporating citral essential oil. Journal of Food and Drug Analysis. 2018;(1):82–9.
53.
Ma Q, Davidson P, Zhong Q. Nanoemulsions of thymol and eugenol coemulsified by lauric arginate and lecithin. Food Chemistry. 2016;167–73.
54.
Magnuson B, Jonaitis T, Card J. A brief review of the occurrence, use, and safety of food-related nanomaterials. Journal of Food Science. 2011;(6):126-R133.
55.
Majeed H, Liu F, Hategekimana J, Sharif H, Qi J, Ali B, et al. Bactericidal action mechanism of negatively charged food grade clove oil nanoemulsions. Food Chemistry. 2016;75–83.
56.
Mason T, Wilking J, Meleson K, Chang C, Graves S. Nanoemulsions: Formation, structure, and physical properties. Journal of Physicscondensed Matter. 2006;(41):635-R666.
57.
Mcclements D. Food emulsions: Principles, practices, and techniques. 2015;
58.
Mcclements D. Annual review of food science and technology. Annual Review of Food Science and Technology. 2010;241–69.
59.
Mcclements D. Nanoemulsions versus microemulsions: Terminology, differences, and similarities. Soft matter. 2012;(6):1719–29.
60.
Mcclements D, Rao J. Foodgrade nanoemulsions: Formulation, fabrication, properties, performance, biological fate, and potential toxicity. Critical Reviews in Food. Science and Nutrition. 2011;(4):285–330.
61.
Miller C. Spontaneous emulsification produced by diffusion-a review. Colloids and Surfaces. 1988;(1):80173–5.
62.
Moghimi R, Aliahmadi A, Mcclements D, Rafati H. Investigations of the effectiveness of nanoemulsions from sage oil as antibacterial agents on some food borne pathogens. LWT-Food Science and Technology. 2016;69–76.
63.
Moraes-Lovison M, Marostegan L, Peres M, Menezes I, Ghiraldi M, Rodrigues R, et al. Nanoemulsions encapsulating oregano essential oil: Production, stability, antibacterial activity and incorporation in chicken pate. 2017;233–40.
64.
Myers D. Surfactant science and technology. 2005;
65.
Nejadmansouri M, Hosseini S, Niakosari M, Yousefi G, Golmakani M. Physicochemical properties and storage stability of ultrasoundmediated wpi-stabilized fish oil nanoemulsions. Food Hydrocolloids. 2016;801–11.
66.
Noori S, Zeynali F, Almasi H. Antimicrobial and antioxidant efficiency of nanoemulsion-based edible coating containing ginger (zingiber officinale) essential oil and its effect on safety and quality attributes of chicken breast fillets. Food Control. 2018;312–20.
67.
Oehlke K, Adamiuk M, Behsnilian D, Graef V, Mayer-Miebach E, Walz E, et al. Potential bioavailability enhancement of bioactive compounds using food-grade engineered nanomaterials: A review of the existing evidence. Food & IJFS October. 2014;(7):1341–59.
68.
Oh Y, Oh Y, Song A, Won J, Song K, Min S. Comparison of effectiveness of edible coatings using emulsions containing lemongrass oil of different size droplets on grape berry safety and preservation. 2017;742–50.
69.
Otoni C, Avena-Bustillos R, Olsen C, Bilbao-Sainz C, Mchugh T. Mechanical and water barrier properties of isolated soy protein composite edible films as affected by carvacrol and cinnamaldehyde micro and nanoemulsions. Food Hydrocolloids. 2016;72–9.
70.
Otoni C, De Moura M, Aouada F, Camilloto G, Cruz R, Lorevice M, et al. Antimicrobial and physicalmechanical properties of pectin/papaya puree/cinnamaldehyde nanoemulsion edible composite films. Food Hydrocolloids. 2014;188–94.
71.
Otoni C, Pontes S, Medeiros E, Soares N. Edible films from methylcellulose and nanoemulsions of clove bud (syzygium aromaticum) and oregano (origanum vulgare) essential oils as shelf life extenders for sliced bread. Journal of Agricultural and Food Chemistry. 2014;(22):5214–9.
72.
Ozogul Y, Yuvka I, Ucar Y, Durmus M, Kosker A, Oz M, et al. Evaluation of effects of nanoemulsion based on herb essential oils (rosemary, laurel, thyme and sage) on sensory, chemical and microbiological quality of rainbow trout (oncorhynchus mykiss) fillets during ice storage. 2017;677–84.
73.
Pagan E, Berdejo D, Espina L, Garcia-Gonzalo D, Pagan R. Antimicrobial activity of suspensions and nanoemulsions of citral in combination with heat or pulsed electric fields. Letters in Ap-plied Microbiology. 2018;(1):63–70.
74.
Perumalla A, Hettiarachchy N. Green tea and grape seed extractspotential applications in food safety and quality. Food Research International. 2011;(4):827–39.
75.
Pimentel-Gonzalez D, Aguilar-Garcia M, Aguirre-Alvarez G, Salcedo-Hernandez R, Guevara-Arauza J, Campos-Montiel R. The process and maturation stability of chihuahua cheese with antioxidants in multiple emulsions. Journal of Food Processing and Preservation. 2015;(6):1027–35.
76.
Pradhan N, Singh S, Ojha N, Shrivastava A, Barla A, Rai V, et al. Facets of nanotechnology as seen in food processing, packaging, and preservation industry. Biomed Research International. 2015;
77.
Qian C, Mcclements D. Formation of nanoemulsions stabilized by model food-grade emulsifiers using high-pressure homogenization: Factors affecting particle size. Food Hydrocolloids. 2011;(5):1000–8.
78.
Raj A, Ragavi J, Rubila S, Tirouthchelvamae D, Ranganathan T. Recent trends in nanotechnology applications in foods. IJERT. 2013;(10):956–61.
79.
Ramos M, Jimenez A, Peltzer M, Garrigos M. Development of novel nano-biocomposite antioxidant films based on poly (lactic acid) and thymol for active packaging. Food Chemistry. 2014;149–55.
80.
Ranjan S, Dasgupta N, Ramalingam C, Kumar A. Chap. Nanoemulsions in Food Science and Nutrition. 2017;147–52.
81.
Rao J, Mcclements D. Food-grade microemulsions, nanoemulsions and emulsions: Fabrication from sucrose monopalmitate & lemon oil. Food Hydrocolloids. 2011;(6):1413–23.
82.
Raviadaran R, Chandran D, Shin L, Manickam S. Optimization of palm oil in water nano-emulsion with curcumin using microfluidizer and response surface methodology. LWT-Food Science and Technology. 2018;58–65.
83.
Roger K, Cabane B. Why are hydrophobic/water interfaces negatively charged? Angewandte Chemie. 2012;5625–8.
84.
Rogers M. Current Opinion in Food Science. 2016;14–9.
85.
Roy A, Guha P. Formulation and characterization of betel leaf (piper betle l.) essential oil based nanoemulsion and its in vitro antibacterial efficacy against selected food pathogens. Journal of Food Processing Preservation. 2018;(6):42.
86.
Salvia-Trujillo L, Verkempinck S, Zhang X, Van Loey A, Grauwet T, Hendrickx M. Comparative study on lipid digestion and carotenoid bioaccessibility of emulsions, nanoemulsions and vegetable-based in situ emulsions. Food Hydrocolloids. 2019;119–28.
87.
Salvia-Trujillo L, Rojas-Graue A, Soliva-Fortuny M, Martin-Belloso R, O. Use of antimicrobial nanoemulsions as edible coatings: Impact on safety and quality attributes of fresh-cut fuji apples. Postharvest Biology and Technology. 2015;8–16.
88.
Sari T, Mann B, Kumar R, Singh R, Sharma R, Bhardwaj M, et al. Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocolloids. 2015;540–6.
89.
Seow Y, Yeo C, Chung H, Yuk HG. Plant essential oils as active antimicrobial agents. Critical Reviews in Food Science and Nutrition. 2014;(5):625–44.
90.
Sessa M, Casazza A, Perego P, Tsao R, Ferrari G, Donsi F. Exploitation of polyphenolic extracts from grape marc as natural antioxidants by encapsulation in lipid-based nanodelivery systems. Food and Bioprocess Technology. 2013;(10):2609–20.
91.
Severino R, Ferrari G, Vu K, Donsi F, Salmieri S, Lacroix M. Antimicrobial effects of modified chitosan based coating containing nanoemulsion of essential oils, modified atmosphere packaging and gamma irradiation against escherichia coli o157:h7 and salmonella typhimurium on green beans. Food Control. 2015;215–22.
92.
Severino R, Vu K, Donsi F, Salmieri S, Ferrari G, Lacroix M. Antimicrobial effects of different combined nonthermal treatments against listeria monocytogenes in broccoli florets. Journal of Food Engineering. 2014;1–10.
93.
Shadman S, Hosseini S, Langroudi H, Shabani S. Evaluation of the effect of a sunflower oil-based nanoemulsion with zataria multiflora boiss. essential oil on the physicochemical properties of rainbow trout (oncorhynchus mykiss) fillets during cold storage. 2017;511–7.
94.
Shah P, Bhalodia D, Shelat P. Nanoemulsion: A pharmaceutical review. Systematic Reviews in Pharmacy. 2010;
95.
Shakeel F, Ramadan W, Faisal M, Rizwan M, Faiyazuddin M, Mustafa G, et al. Transdermal and topical delivery of anti-inflammatory agents using nanoemulsion/microemulsion: An updated review. Current Nanoscience. 2010;(2):184–98.
96.
Shao Y, Wu C, Wu T, Li Y, Chen S, Yuan C, et al. Eugenol-chitosan nanoemulsions by ultrasound-mediated emulsification: Formulation, characterization and antimicrobial activity. Carbohydrate IJFS October. 2018;105–24.
97.
Polymers. :144–52.
98.
Silva E, Rosa M, Meireles M. Ultrasound-assisted formation of emulsions stabilized by biopolymers. Current Opinion in Food Science. 2015;50–9.
99.
Silva H, Poejo J, Pinheiro A, Donsi F, Serra A, Duarte C, et al. Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion. Journal of Functional Foods. 2018;605–13.
100.
Silva H, Cerqueira M, Vicente A. Nanoemulsions for food applications: Development and characterization. Food and Bioprocess Technology. 2012;(3):854–67.
101.
Singh H. Nanotechnology applications in functional foods; opportunities and challenges. Preventive nutrition and food science. 2016;1–8.
102.
Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma M. Nanoemulsions. Current Opinion in Colloid & Interface Science. 2005;(3):102–10.
103.
Sonneville-Aubrun O, Babayan D, Bordeaux D, Lindner P, Rata G, Cabane B. Phase transition pathways for the production of 100 nm oil-in-water emulsions. Physical Chemistry Chemical Physics. 2009;(1):101–10.
104.
Sugumar S, Ghosh V, Mukherjee A, Chandrasekaran N. Essential oil-based nanoemulsion formation by low-and highenergy methods and their application in food preservation against food spoilage microorganisms. 2016;
105.
Sugumar S, Nirmala J, Ghosh V, Anjali H, Mukherjee A, Chandrasekaran N. Bio-based nanoemulsion formulation, characterization and antibacterial activity against food-borne pathogens. Journal of Basic Microbiology. 2013;(8):677–85.
106.
Surh J, Decker E, Mcclements D. Utilisation of spontaneous emulsification to fabricate lutein-loaded nanoemulsion-based delivery systems: Factors influencing particle size and colour. International Journal of Food Science and Technology. 2017;(6):1408–16.
107.
Syed I, Sarkar P, Szakal C, Roberts S, Westerhoff P, Bartholomaeus A, et al. Ultrasonicationassisted formation and characterization of geraniol and carvacrol-loaded emulsions for enhanced antimicrobial activity against food-borne pathogens. Chemical Papers. 2018;(10):3128–35.
108.
Tadros T, Izquierdo R, Esquena J, Solans C. Advances in Colloid and Interface Science. 2004;303–18.
109.
Tan S, Masoumi H, Karjiban R, Stanslas J, Kirby B, Basri M, et al. Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface methodology and evaluation of its stability. Ultrasonics Sonochemistry. 2016;299–308.
110.
Tastan O, Ferrari G, Baysal T, Donsi F. Understanding the effect of formulation on functionality of modified chitosan films containing carvacrol nanoemulsions. Food Hydrocolloids. 2016;756–71.
111.
Taylor P. Ostwald ripening in emulsions. Advances in Colloid and Interface Science. 1998;(2):35–9.
112.
Guidance for industry e considering whether an fda-regulated product in-volves the application of nanotechnology. 2014;
113.
Valdes A, Mellinas A, Ramos M, Burgos N, Jimenez A, Garrigos M. Use of herbs, spices and their bioactive compounds in active food packaging. 2015;(50):40324–35.
114.
Xue J, Davidson P, Zhong Q. Inhibition of escherichia coli o157:h7 and listeria monocytognes growth in milk and cantaloupe juice by thymol nanoemulsions prepared with gelatin and lecithin. Food Control. 2017;(B):1499–506.
115.
Yang Y, Leser M, Sher A, Mc-Clements D. Formation and stability of emulsions using a natural small molecule surfactant: Quillaja saponin (qnaturale (r)). Food Hydrocolloids. 2013;(2):589–96.
116.
Yin LJ, Chu BS, Kobayashi I, Nakajima M. Performance of selected emulsifiers and their combinations in the preparation of beta-carotene nanodispersions. Food Hydrocolloids. 2009;(6):1617–22.
117.
Zahi M, Wan P, Liang H, Yuan Q. Formation and stability of d-limonene organogel-based nanoemulsion prepared by a high-pressure homogenizer. Journal of agricultural and food chemistry. 2014;(52):12563–9.
118.
Zambrano-Zaragoza M, Gutiérrez-Cortez E, Del Real A, González-Reza R, Galindo-Pérez M, Quintanar-Guerrero D. Fresh-cut red delicious apples coating using tocopherol/mucilage nanoemulsion: Effect of coating on polyphenol oxidase and pectin methylesterase activities. Food Research International. 2014;974–83.
119.
Zhang S, Zhang M, Fang Z, Liu Y. Preparation and characterization of blended cloves/cinnamon essential oil nanoemulsions. 2017;316–22.
120.
Zhang Z, Vriesekoop F, Yuan Q, Liang H. Effects of nisin on the antimicrobial activity of d-limonene and its nanoemulsion. Food chemistry. 2014;307–12.
121.
Ziani K, Chang Y, Mclandsborough L, Mcclements D. Influence of surfactant charge on antimicrobial efficacy of surfactant-stabilized thyme oil nanoemulsions. Journal of agricultural and food chemistry. 2011;(11):6247–55.
122.
IJFS October. 2019;105–24.

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