In order to investigate the solubility of Stevioside and Rebaudioside A in different solvents (ethanol, water, ethanol:water 30:70 and ethanol:water 70:30), supersaturated solutions of pre-crystalized steviol glycosides were maintained at different temperatures (from 5 °C to 50 °C) to reach equilibrium. Under these conditions significant differences were found in the extent of solubility. Rebaudioside A was poorly soluble in ethanol and water, and Stevioside was poorly soluble in water. Solvent mixtures more effectively promoted solubilisation, and a significant effect of temperature on solubility was observed. The two steviol glycosides showed higher solubilities and this behavior was promoted by the presence of the other sweetener. The polarity indices of the solvents were determined, and helped to explain the observed behavior. Several solute-solvent and solute-solute interactions can occur, along with the incidence of a strong affinity between solvents. The obtained results are in accordance with technological applications of ethanol, water and their binary mixtures for Stevioside and Rebaudioside A separations.
Abelyan V, Markosyan A, Abelyan L. High-purity Rebaudioside D. United States Patent Database. 2011.
2.
Carakostas M, Prakash I, Kinghorn D, Wu C, Soejarto D. Alternative sweeteners, fourth edition. CRC Press; 2012. p. 159–80.
3.
Chranioti C, Chanioti S, Tzia C. Microencapsulation of steviol glycosides (Stevia rebaudiana Bertoni) by a spray drying method -Evaluation of encapsulated products and prepared syrups. International Journal of Food Studies. 2015. p. 212–20.
4.
Chranioti C, Chanioti S, Tzia C. Comparison of spray, freeze and oven drying as a means of reducing bitter aftertaste of steviol glycosides (derived from Stevia rebaudiana Bertoni plant) -Evaluation of the final products. Food Chemistry. 2016. p. 1151–8.
5.
Da Silva D, Ricken I, Silva M, Machado V. Solute-solvent and solvent-solvent interactions in the preferential solvation of Brooker’s merocyanine in binary solvent mixtures. Journal of Physical Organic Chemistry. 2002. p. 420–7.
6.
Evans J, Hahn J, Myerson A, Oolman T, Rhonemus T, Storo K, et al. Method for producing purified Rebaudioside A compositions using solvent / antisolvent crystallization. United States Patent Database. Patent Application Publication; 2010.
7.
Goto A, Clemente E. Influência do Rebaudiosídeo A na solubilidade e no sabor do Esteviosídeo. Food Science and Technology (Campinas). 1998. p. 3–6.
8.
Helbing W, Burkart A. Tablas químicas: para laboratorios e industria. 1985. p. 132.
9.
Jackson M, Francis G, Chase G. Pure and substantially pure rebaudioside A. United States Patent Database. 2011.
10.
Jones A. Butterworth-Heinemann, 1st Edition. Elsevier; 2002. p. 61–2.
11.
Jonnala K, Babu G, Vijay K, Paramvir S. Process for production of steviosides from Stevia rebaudiana Bertoni. United States Patent Database. Patent Application Publication US; 2006.
12.
Kerton F. Alternative solvents for green chemistry. The Royal Society of Chemistry. 2013. p. 1–30.
13.
Kienle U. Method of making a natural sweetener based on Stevia rebaudiana, and use thereof. United States Patent Database. Patent Aplication Publication US; 1992.
14.
Kinghorn A. Overview: Physical properties, solubility and stability of Stevioside. CRC Press; 2002. p. 8–9.
15.
Kolb N, Herrera J, Ferreyra D, Uliana R. Analysis of sweet diterpene glycosides from Stevia rebaudiana: Improved HPLC method. Journal of Agricultural and Food Chemistry. 2001. p. 4538–41.
16.
Koshima C, Nakamoto K, Aracava K, Oliveira A, Rodrigues C. Fractionation of Bergamot and Lavandin Crude Essential Oils by Solvent Extraction: Phase Equilibrium at 298.2 K. Journal of Chemical and Engineering Data. 2015. p. 37–46.
17.
Kumar S. Method for recovery of Stevioside. United States Patent Database. Patent Application Publication US; 1986.
18.
Langhals H. Description of properties of binary solvent mixtures. (Chap. 42 -Similarity models in organic chemistry, biochemistry and related fields. Elsevier Science Publishers; 1991. p. 287–98.
19.
Lee T. Method to Increase Solubility Limit of Rebaudioside D in an Aqueous Solution. United States Patent Database. 2011.
20.
Markosyan A. High-purity Rebaudioside C and process for purification the same. United States Patent Database. 2011.
21.
Persinos G. Method of producing Stevioside. United States Patent Database. Patent Application Publication US; 1973.
22.
Poling B, Thomson G, Friend D, Rowley R, Wilding W. McGraw-Hill Companies Editions. Perry’s Chemical Engineers’ Handbook. McGraw-Hill; 2008. p. 2–117.
23.
Prakash I, Dubois G, Cios J, Wilkens K, Fosdick L. Development of rebiana, a natural, non-caloric sweetener. Food and Chemical Toxicology. 2008. p. 75-S82.
24.
Prakash I, G, D, G, Upreti K, M. Rebaudioside A composition and method for purifying rebaudioside A. United States Patent Database. Patent Application Publication US; 2015.
25.
Rai C, Majumdar G, De S. Optimization of Process Parameters for Wa-ter Extraction of Stevioside using Response Surface Methodology. Separation Science and Technology. 2012. p. 1014–22.
26.
Reichardt C. Solvents and Solvent Effects in Organic Chemistry: Third, Updated and Enlarged Edition. Chap. Appendix. ACS Publications; 2004. p. 487–9.
27.
Reichardt C. Solvents and Solvent Effects in Organic Chemistry: Third, Updated and Enlarged Edition. ACS Publications; 2004. p. 389–470.
28.
Uchiyama H, Tozuka Y, Nishikawa M, Takeuchi H. Nanocomposite formation between alpha-glucosyl stevia and surfactant improves the dissolution profile of poorly water-soluble drug. International Journal of Pharmaceutics. 2012. p. 183–6.
29.
Upreti M, Strassburger K, Chen Y, Wu S, Prakash I. Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin. International Journal of Molecular Sciences. 2011. p. 7529–53.
30.
Zhang F, Koh G, Jeansonne D, Hollingsworth J, Russo P, Vicente G, et al. A Novel Solubility-Enhanced Curcumin Formulation Showing Stability and Maintenance of Anticancer Activity. Journal of Pharmaceutical Sciences. 2011. p. 2778–89.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
