Food scientists and technologists are actively engaged in examining and developing nanotechnologies for applications such as novel functional ingredients and nutrient delivery systems, safety testing, packaging, and authenticity/authentication at an ever-increasing pace. However, before these new products/technologies are commercialised, rigorous safety testing and risk/benefit analysis are required to ensure that public and environmental concerns are addressed. This review provides an overview of food nanoscience and technology including a brief history, education, definitions pertaining to policy and regulation, and applications. The most recent findings and advances are emphasised, focussing on bioactives' delivery. In addition, proposed directions in the area of nano-based targeting of pathogens for food safety as well as medical foods are discussed. As food nanoscience and technology has been extensively reviewed in recent years, specific case examples will be limited to those reported within the past year.
Aarestrup F, Wegener H, Collignon P. Resistance in bacteria of the food chain: epidemiology and control strategies. Expert Review of Anti-Infective Therapy. 2008. p. 733–50.
2.
Abdulkarim M, Chitneni M, Mahdi E, Yam M, Faisal A, Salman I, et al. Formulation and characterization of palm oil esters based nano-cream for topical delivery of piroxicam. International Journal of Drug Delivery. 2011.
3.
Abeylath S, Turos E. Drug delivery approaches to overcome bacterial resistance to beta-lactam antibiotics. Expert Opinion on Drug Delivery. 2008. p. 931–49.
4.
Altunbas A, Lee S, Rajasekaran S, Schneider J, Pochan D. Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles. Biomaterials. 2011. p. 5906–14.
5.
Armstead A, Li B. Nanomedicine as an emerging approach against intracellular pathogens. International Journal of Nanomedicine. 2011. p. 3281–93.
6.
Augustin M, Hemar Y. Nanoand micro-structured assemblies for encapsulation of food ingredients. Chemical Society Reviews. 2009. p. 902–12.
7.
Basile V, Ferrari E, Lazzari S, Belluti S, Pignedoli F, Imbriano C. Curcumin derivatives: Molecular basis of their anti-cancer activity. Biochemical Pharmacology. 2009. p. 1305–15.
8.
Bhatia A, Shard S, Chopra D, Mishra T. Chitosan nanoparticles as Carrier of Immunorestoratory plant extract: synthesis, characterization and Immunorestoratory efficacy. International Journal of Drug Delivery. 2011.
9.
Blasco C, Picó Y. Trac-Trends in Analytical Chemistry, 30 (1, SI). 2011. p. 84–99.
10.
Booth B, Boesmanfinkelstein M, Finkelstein R. Vibrio cholerae hemagglutinin/protease nicks cholera enterotoxin. Infection and Immunity. 1984. p. 558–60.
11.
Bouwmeester H, Dekkers S, Noordam M, Hagens W, Bulder A, De Heer C, et al. Review of health safety aspects of nanotechnologies in food production. Regulatory Toxicology and Pharmacology. 2009. p. 52–62.
12.
Bradley E, Castle L, Chaudhry Q. Applications of nanomaterials in food packaging with a consideration of opportunities for developing countries. Trends in Food Science & Technology. 2011. p. 604–10.
13.
Brehm-Stecher B, F. Food nanotechnology. The manufacturing confectioner, October. 2009. p. 37–50.
14.
Brunder W, Schmidt H, Karch H. EspP, a novel extracellular serine protease of enterohaemorrhagic Escherichia coli O157:H7 cleaves human coagulation factor V. Molecular Microbiology. 1997. p. 767–78.
15.
Calvo J, Luis Lavandera J, Agueeros M, Irache J. Cyclodextrin/poly(anhydride) nanoparticles as drug carriers for the oral delivery of atovaquone. Biomedical Microdevices. 2011. p. 1015–25.
16.
Card J, Jonaitis T, Tafazoli S, Magnuson B. An appraisal of the published literature on the safety and toxicity of food-related nanomaterials. Critical Reviews in Toxicology. 2011. p. 20–49.
17.
Cavalli R, Trotta F, Tumiatti W. 23rd Cyclodextrin Symposium. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2006. p. 209–13.
18.
Chaudhary A, Sutaria D, Huang Y, Wang J, Prabhu S. Chemoprevention of Colon Cancer in a Rat Carcinogenesis Model Using a Novel Nanotechnology-Based Combined Treatment System. Cancer Prevention Research. 2011. p. 1655–64.
19.
Chevalier-Lucia D, Blayo C, Gracia-Julia A, Picart-Palmade L, Dumay E. Processing of phosphocasein dispersions by dynamic high pressure: Effects on the dispersion physico-chemical characteristics and the binding of alpha-tocopherol acetate to casein micelles. Innovative Food Science & Emerging Technologies. 2011. p. 416–25.
20.
Claonadh N, Casey A, Lyons S, Higginbotham C, Mukherjee S, Chambers G. Nano-enhanced food contact materials and the in vitro toxicity to human intestinal cells of nano-zno at low dose. Journal of Physics: Conference Series. 2011. p. 12038.
21.
Second implementation report. COM; 2009. p. 607.
22.
Cozzoli A, Rolland J, Capogrosso R, Sblendorio V, Longo V, Simonetti S, et al. Evaluation of potential synergistic action of a combined treatment with alpha-methylprednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy. Neuropathology and Applied Neurobiology. 2011. p. 243–56.
23.
Desai P. Molecular interactions of salmonella with the host epithelium in presence of commensals. (Doctoral dissertation). 2011.
24.
Dodds P, Rathjen J. Plant immunity: towards an integrated view of plant-pathogen interactions. Nature Reviews Genetics. 2010. p. 539–48.
25.
Dressman J, Reppas C. S73-S80. Meeting on Frontiers in Biopharmacy. European Journal of Pharmaceutical Sciences. 2000.
26.
Duncan T. Applications of nanotechnology in food packaging and food safety: Barrier materials, antimicrobials and sensors. Journal of Colloid and Interface Science. 2011. p. 1–24.
27.
Duncan T. The communication challenges presented by nanofoods. Nature Nanotechnology. p. 683–8.
28.
El-Sherbiny I, Abdel-Mogib M, Dawidar AA, Elsayed A, Smyth H. Biodegradable pHresponsive alginate-poly (lactic-co-glycolic acid) nano/micro hydrogel matrices for oral delivery of silymarin. Carbohydrate Polymers. 2011. p. 1345–54.
29.
Elzoghby A, El-Fotoh W, Elgindy N. Casein-based formulations as promising controlled release drug delivery systems. Journal of Controlled Release. 2011. p. 206–16.
30.
Esmaili M, Ghaffari S, Moosavi-Movahedi Z, Atri M, Sharifizadeh A, Farhadi M, et al. Beta casein-micelle as a nano vehicle for solubility enhancement of curcumin; food industry application. Lwt-Food Science and Technology. 2011. p. 2166–72.
31.
Fathi M, Mozafari M, Mohebbi M. Nanoencapsulation of food ingredients using lipid based delivery systems. Trends in Food Science & Technology. 2012. p. 13–27.
32.
Feynman R. There’s plenty of room at the bottom. Caltech engineering and science. 1960. p. 22–36.
33.
Flendrig L, Marshman C, Velikov K, Winter I. Calcium fortified food product and additive. United States of America. Patent number US 20090238947 (Assigned to Conopco. Inc. on May. 2009.
34.
Franchi G, Jr, Moraes C, Toreti V, Daugsch A, Nowill A, et al. Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay. Evidence-Based Complementary And Alternative Medicine. 2012.
35.
George C, Kuriakose S, George S, Mathew T. Antifungal activity of silver nanoparticle-encapsulated betacyclodextrin against human opportunistic pathogens. Supramolecular Chemistry. 2011. p. 593–7.
36.
Gimzewski J, Vesna V. The nanoneme syndrome: Blurring of fact and fiction in the construction of a new science. Technoetic arts. 2003. p. 7–24.
37.
Smith G, Kline. Wellvone%20750mg% 205ml%20oral%20suspension/#FORM. 2010.
38.
Grundy S, Mok H. Lipoprotein metabolism. Springer-Verlag; 1976. p. 112–8.
39.
Halpern M, Gancz H, Broza M, Kashi Y. Vibrio cholerae hemagglutinin/protease degrades chironomid egg masses. Applied and Environmental Microbiology. 2003. p. 4200–4.
40.
Harris D, Brashears M, Garmyn A, Brooks J, Miller M. Microbiological and organoleptic characteristics of beef trim and ground beef treated with acetic acid, lactic acid, acidified sodium chlorite, or sterile water in a simulated commercial processing environment to reduce Escherichia coli. Meat Science. H7 and Salmonella; 2012. p. 783–8.
41.
Policy statement on Health Canada’s working definition for nanomaterial (version 2). 2011.
42.
Php Hritonenko V, Stathopoulos C. Summary of comments received on the interim policy statement on Health Canada’s working definition for nanomaterials -March to. Molecular Membrane Biology. 2011. p. 395–406.
43.
Huang Z, Yu B, Feng Q, Li S, Chen Y, Luo L. In situ-forming chitosan/nano-hydroxyapatite/collagen gel for the delivery of bone marrow mesenchymal stem cells. Carbohydrate Polymers. 2011. p. 261–7.
44.
Hube B, Naglik J. Candida albicans proteinases: Resolving the mystery of a gene family. Microbiology. 2001. p. 1997–2005.
45.
Hueck C. Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiology and molecular biology reviews. 2001. p. 379–433.
46.
Jackson M, Burrell K, Gaddie I, Richardson S. Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A. Clinical ophthalmology. 2011. p. 1201–6.
47.
Javed S, Kohli K, Ali M. Reassessing Bioavailability of Silymarin. Alternative Medicine Review. 2011. p. 239–49.
48.
Kanwar J, Long B, Kanwar R. The Use of Cyclodextrins Nanoparticles for Oral Delivery. Current Medicinal Chemistry. 2011. p. 2079–85.
49.
Kennedy M, Volz P, Edwards C, Yangey R. Mechanisms of association of Candida albicans with intestinal mucosa. Journal of Medical Microbiology. 1987. p. 333–41.
50.
Kim C, Kim C, Cho Y, Choi S, Choi A. Nanoemulsion and nanoparticle containing plant essential oil and method of production thereof. Europe. Patent number EP 2173194 (Assigned to. Korea Food Research Institute on September. 2011.
51.
Knodler L, Vallance B, Celli J, Winfree S, Hansen B, Montero M, et al. Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia. Proceedings of the National Academy of Sciences of the United States of America. 2010. p. 17733–8.
52.
Kost J, Langer R. Responsive polymeric delivery systems. Advanced Drug Delivery Reviews. 2001. p. 125–48.
53.
Kumar A, Vemula P, Ajayan P, John G. Silver-nanoparticleembedded antimicrobial paints based on vegetable oil. Nature Materials. 2008. p. 236–41.
54.
Kurkov S, Ukhatskaya E, Loftsson T. Drug/cyclodextrin: beyond inclusion complexation. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2011. p. 297–301.
55.
Kurzawa-Zegota M, Najafzadeh M, Baumgartner A, Anderson D. The protective effect of the flavonoids on foodmutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food and Chemical Toxicology. 2012. p. 124–9.
56.
Lagaron J, Lopez-Rubio A. Nanotechnology for bioplastics: opportunities, challenges and strategies. Trends in Food Science & Technology. 2011. p. 611–7.
57.
Lakkis J, García A. Calcium fortified food product and additive. Clarke, Modet & Co. Microcapsules containing salts for food products. Europe. Patent number EP. 2011.
58.
Lakshminarayanan R, Kesselman E, Cohen R, Athappan P, Shimoni E. Curdlan complexes as a potential food-grade delivery system: Genistein case study. Therapeutic delivery. 2011. p. 181–92.
59.
Langer R, Tirrell D. Designing materials for biology and medicine. Nature. 2004. p. 487–92.
60.
Lansdown A. Silver I: Its antibacterial properties and mechanism of action. Journal of wound care. 2002. p. 125–30.
61.
Lantz R, Chen G, Solyom A, Jolad S, Timmermann B. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005. p. 445–52.
62.
Lawhon S, Khare S, Rossetti C, Everts R, Galindo C, Luciano S, et al. Role of SPI-1 Secreted Effectors in Acute Bovine Response to Salmonella enterica Serovar Typhimurium: A Systems Biology Analysis Approach. Plos One. 2011.
63.
Lecaille F, Kaleta J, Brömme D. Human and parasitic papain-like cysteine proteases: Their role in physiology and pathology and recent developments in inhibitor design. Chemical Reviews. 2002. p. 4459–88.
64.
Lees A, Mok H, Lees R, Mccluskey M, Grundy S. Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis. 1977. p. 325–38.
65.
Li M, Patton D, Cosgrove-Sweeney Y, Ratner D, Rohan L, Cole A, et al. Incorporation of the HIV-1 Microbicide Cyanovirin-N in a Food Product. Jaids-Journal of Acquired Immune Deficiency Syndromes. 2011. p. 379–84.
66.
Lin N, Huang J, Chang P, Anderson D, Yu J. Preparation, Modification, and Application of Starch Nanocrystals in Nanomaterials: A Review. Journal Of Nanomaterials. 2011.
67.
Lin Q, Li B, Song H, Wu H. Determination of silver in nano-plastic food packaging by microwave digestion coupled with inductively coupled plasma atomic emission spectrometry or inductively coupled plasma mass spectrometry. Food Additives and Contaminants Part A-chemistry. Analysis Control Exposure & Risk Assessment. 2011. p. 1123–8.
68.
Lindel D. The food and beverage industry in Germany. Germany Trade and Invest; 2011.
69.
Lu Q, Li DC, Jiang JG. Preparation of a Tea Polyphenol Nanoliposome System and Its Physicochemical Properties. Journal of Agricultural and Food Chemistry. 2011. p. 13004–11.
70.
Macleod G, Fell J, Collett J, Sharma H, Smith A. Selective drug delivery to the colon using pectin : chitosan : hydroxypropyl methylcellulose film coated tablets. International Journal of Pharmaceutics. 1999. p. 196–9.
71.
Magnuson B, Bouwmeester H. Nanotechnology in the agri-food sector. Wiley-VCH Verlag GmbH & Co. KGaA; 2011. p. 171–90.
72.
Magnuson B, Jonaitis T, Card J. A Brief Review of the Occurrence, Use, and Safety of Food-Related Nanomaterials. Journal of Food Science. 2011. p. 126-R133.
73.
Makhlof A, Tozuka Y, Takeuchi H. Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. European Journal of Pharmaceutical Sciences. 2011. p. 445–51.
74.
Marshall B, Levy S, Miettinen T, Puska P, Gylling H, Vanhanen H, et al. Reduction Of Serum-Cholesterol with Sitostanol-Ester Margarine in a Mildly Hypercholesterolemic Population. Clinical Microbiology Reviews. New England Journal of Medicine; 2011. p. 1308–12.
75.
Milojevic S, Newton J, Cummings J, Gibson G, Botham R, Ring S, et al. Amylose as a coating for drug delivery to the colon: Preparation and in vitro evaluation using 5-aminosalicylic acid pellets. Journal of Controlled Release. 1996. p. 75–84.
76.
Mishra B, Patel B, Tiwari S. Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nananomedicine-Nanotechnology Biology and Medicine. 2010. p. 9–24.
77.
Morris V. Emerging roles of engineered nanomaterials in the food industry. Trends in Biotechnology. 2011. p. 509–16.
78.
Murugeshu A, Astete C, Leonardi C, Morgan T, Sabliov C. Chitosan/PLGA particles for controlled release of alpha-tocopherol in the GI tract via oral administration. Nanomedicine. 2011. p. 1513–28.
79.
Nah J, Jung T, Jang M, Jeong Y. Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof. United States of America. Patent number US 7883723B2 (Assigned to Nah. J., Jung, T.R. & Jang, M. on February. 2011.
80.
Nanotechnology timeline. National Nanotechnology Institute; 2011.
81.
Neethirajan S, Jayas D. Nanotechnology for the Food and Bioprocessing In-dustries. Food and Bioprocess Technology. 2011. p. 39–47.
82.
Pahari B, Chakraborty S, Sengupta P. Encapsulation of 3-hydroxyflavone in gamma-cyclodextrin nanocavities: Excited state proton transfer fluorescence and molecular docking studies. Journal of Molecular Structure. 2011. p. 483–8.
83.
Plapied L, Duhem N, Des Rieux A, Préat V. Fate of polymeric nanocarriers for oral drug delivery. Current Opinion In Colloid & Interface Science. 2011. p. 228–37.
84.
Powell J, Clozel J, Muller R, Kuhn H, Hefti F, Hosang M, et al. Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury. Science. 1989. p. 186–8.
85.
Prabaharan M. } Project on Emerging Nanotechnologies. International Journal Of Biological Macromolecules. 2011. p. 117–24.
86.
Puttamreddy S. Genetic analysis of Escherichia coli o157:h7 biofilm formation. (Doctoral dissertation). 2011.
87.
Pytlikzillig L, Tomkins A. Public Engagement for Informing Science and Technology Policy: What Do We Know, What Do We Need to Know, and How Will We Get There? Review of Policy Research. 2011. p. 197–217.
88.
Quilliam R, Williams A, Avery L, Malham S, Jones D. Unearthing human pathogens at the agricultural-environment interface: A review of current methods for the detection of Escherichia coli O157 in freshwater ecosystems. Agriculture Ecosystems & Environment. 2011. p. 354–60.
89.
Rashidi L, Khosravi-Darani K. The Applications of Nanotechnology in Food Industry. Critical Reviews in Food Science and Nutrition. 2011. p. 723–30.
90.
Ravindranath S, Wang Y, Irudayaraj J. SERS driven cross-platform based multiplex pathogen detection. Sensors and Actuators B-Chemical. 2011. p. 183–90.
91.
Roco M. The Long View of Nanotechnology Development: The National Nanotechnology Initiative at 10 Years. Springer; 2011. p. 1–28.
92.
Rubinstein A, Radai R. In vitro and in vivo analysis of colon specificity of calcium pectinate formulations. European journal of pharmaceutics and biopharmaceutics. 1995. p. 291–5.
93.
Ruby A, Kuttan G, Babu K, Rajasekharan K, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters. 1995. p. 79–83.
94.
Schneider K, Wehrschuetz-Sigl E, Eichhorn S, Hasmann A, Flock T, Kaufmann F, et al. Bioresponsive systems based on crosslinked polysaccharide hydrogels. Process Biochemistry. 2012. p. 305–11.
95.
Schneider K, Rollett A, Wehrschuetz-Sigl E, Hasmann A, Zankel A, Muehlebach A, et al. Bioresponsive systems based on polygalacturonate containing hydrogels. Enzyme and Microbial Technology. 2011. p. 312–8.
96.
Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). 2010.
97.
Sessa M, Tsao R, Liu R, Ferrari G, Donsi F. Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during in Vitro Digestion. Journal of Agricultural and Food Chemistry. 2011. p. 12352–60.
98.
Shell W, Bullias D, Charuvastra E, May L, Silver D. A Randomized, Placebo-Controlled Trial of an Amino Acid Preparation on Timing and Quality of Sleep. American Journal of Therapeutics. 2010. p. 133–9.
99.
Shell W, Charuvastra E, Dewood M, May L, Bullias D, Silver D. A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain. American Journal of Therapeutics. 2012. p. 108–14.
100.
Shi M, Cai Q, Yao L, Mao Y, Ming Y, Ouyang G. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biology International. 2006. p. 221–6.
101.
Sikora A, Zielke R, Lawrence D, Andrews P, Sandkvist M. Proteomic Analysis of the Vibrio cholerae Type II Secretome Reveals New Proteins, Including Three Related Serine Proteases. Journal of Biological Chemistry. 2011. p. 16555–66.
102.
Smolander M, Chaudhry Q. Nanotechnologies in food. Cambridge: The Royal Society of Chemistry. 2010. p. 86–101.
103.
Smooker P, Jayaraj R, Pike R, Spithill T. Cathepsin B proteases of flukes: the key to facilitating parasite control? Trends in Parasitology. 2010. p. 506–14.
104.
Sozer N, Kokini J. Nanotechnology and its applications in the food sector. Trends in Biotechnology. 2009. p. 82–9.
105.
Srikanth C, Wall D, Maldonado-Contreras A, Shi H, Zhou D, Demma Z, et al. Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3. Science. 2010. p. 390–3.
106.
Srinivas P, Philbert M, Vu T, Huang Q, Kokini J, Saos E, et al. Nanotechnology Research: Applications in Nutritional Sciences. Journal of Nutrition. 2010. p. 119–24.
107.
Stack C, Dalton J, Robinson M. Advances in Experimental Medicine and Biology. Springer US; 2011. p. 116–35.
108.
Suomalainen M, Haiko J, Kukkonen M, Korhonen T, Lähteenmäki K, Virkola R, et al. Advances in Experimental Medicine and Biology. Springer; 2007. p. 268–78.
109.
Sweeney A, Seal S. Nanoscale science and engineering education. American Scientific; 2008. p. 1–35.
110.
Taniguchi N. Proceedings of the international conference of product engineering Tokyo Part. Japan Society of Precision Engineering; 1974.
111.
Teow Y, Asharani P, Hande M, Valiyaveettil S. Health impact and safety of engineered nanomaterials. Chemical Communications. 2011. p. 7025–38.
112.
The International Organization for Standardization. Official Journal L 275. 2011. p. 126.
113.
Trotta F, Cavalli R, Martina K, Biasizzo M, Vitillo J, Bordiga S, et al. } UCLA History and Special Collections. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2011. p. 189–94.
114.
Ulijn R, Bibi N, Jayawarna V, Thornton P, Todd S, Mart R, et al. Bioresponsive hydrogels. Materials Today. 2007. p. 70049–53.
115.
Medical Foods. U.S. Food and Drug Administration; 2009.
116.
Considering whether an FDA-regulated product involves the application of nanotechnology -Guidance for industry. Report number: ucm257698. U.S. Food and Drug Administration; 2011.
117.
Report number: ucm257563. U.S. Food and Drug Administration; 2011.
118.
Van Putten E, Akbulut D, Bertolotti J, Vos W, Lagendijk A, Mosk A. Scattering Lens Resolves Sub-100 nm Structures with Visible Light. Physical Review Letters. 2011. p. 106.
119.
Van Der Horst M, Schuurmans J, Smid M, Koenders B, Ter Kuile B. De Novo Acquisition of Resistance to Three Antibiotics by Escherichia coli. Microbial Drug Resistance. 2011. p. 141–7.
120.
Vandeputte-Rutten L, Kramer R, Kroon J, Dekker N, Egmond M, Gros P. Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site. Embo Journal. 2001. p. 5033–9.
121.
Wang H, Schaffner D. Antibiotic Resistance: How Much Do We Know and Where Do We Go from Here? Applied and Environmental Microbiology. 2011. p. 7093–5.
122.
Wang R, Tian Z, Chen L. Nanoencapsulations liberated from barley protein microparticles for oral delivery of bioactive compounds. International Journal of Pharmaceutics. 2011. p. 153–62.
123.
Wen J, Anderson S, Du J, Yan M, Wang J, Shen M, et al. Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules. Advanced Materials. 2011. p. 4549.
124.
Wijnhoven S, Peijnenburg W, Herberts C, Hagens W, Oomen A, Heugens E, et al. Nano-silver -a review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology. 2009. p. 109-U78.
125.
Wilkhu J, Mcneil S, Kirby D, Perrie Y. Formulation design considerations for oral vaccines. Therapeutic delivery. 2011. p. 1141–64.
126.
Wlodarska M, Finlay B. Host immune response to antibiotic perturbation of the microbiota. Mucosal Immunology. 2010. p. 100–3.
127.
Woo J, Kim TS, Park JH, Chi SC. Formulation and biopharmaceutical evaluation of silymarin using SMEDDS. Archives of Pharmacal Research. 2007. p. 82–9.
128.
Yan L, Chang P, Zheng P, Ma X. Characterization of magnetic guar gum-grafted carbon nanotubes and the adsorption of the dyes. Carbohydrate Polymers. 2012. p. 1919–24.
129.
Yan L, Chang P, Zheng P. Preparation and characterization of starchgrafted multiwall carbon nanotube composites. Carbohydrate Polymers. 2011. p. 1378–83.
130.
Yoon J, Hovde C. All blood, No stool: enterohemorrhagic Escherichia coli O157 : H7 infection. Journal of Veterinary Science. 2008. p. 219–31.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.